Abstract: Successful information system strategy implementation is the key to organization's survival. It consists of a long-term action plan for achieving the stated aims of an organization. It focuses on business process improvement, increasing efficiencies and controlling cost. It supports business process management and is mostly driven by customer needs. It is one of the main topics that has gathered the attention of practitioners and IS researchers who had conducted various investigations in different domains. Taking this point as a motivation, a detailed study was made to analyse the impact of successful strategic implementations in various organizations and the major influencing factors while its deployment. Following a systematic literature review, the paper focuses on five major influencing factors: organizational culture, leadership, organizational structure, organization communication and IT/IS development. Based on these factors, a case study was done at a healthcare centre in Saudi Arabia. The results showed that the above-listed factors had a very strong impact on IS strategy and policy of the organization.

Keywords: Information systems, strategy, adoption, factor influences, healthcare centre.